患者，男，72岁，前列腺穿刺术后，出现发热，血白细胞增高。送血培养，给头孢曲松，每天2次给药后第四天出现烦躁，意识不清，颈抵抗，腰穿，脑脊液中白细胞增高，中性分类增高。诊断：败血症，化脓性脑膜炎，血培养：大肠埃希菌（ESBL+）治疗用何种抗菌药物

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