女性，30岁，腰痛、尿频、尿急、血压 21.3/13.3kPa (160/100mmHg),尿蛋白（+)， 沉渣红细胞8-10/HP,白细胞15~20/HP。肾盂造影示右肾缩小，肾盏扩张，最可能诊断是

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