患者男，65岁。进行性黄疸3个月，伴中上腹持续性胀感，夜间平卧时加重，消瘦显著。查体:慢性消耗性面容。皮肤、巩膜黄染。腹平坦，脐右上方深压痛，未及块物。Courvoisier征阳性。首先考虑的诊断是

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