患者女，35岁。8年前曾因葡萄胎行清宫，现再次出现阴道不规则出血，间断痰中带血丝，妇检示:阴道壁可见紫蓝色结节，胸片见双肺团块状影，查血hCG大于100000U/L，阴道壁结节活检示未见绒毛结构。该患者首选治疗为

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