患者女，42岁。既往健康，近2个月出现巩膜、皮肤黄染，呈进行性加重，无腹痛，略消瘦，体检见：肝肋下可触及，右上腹扪及肿大之胆囊，无触痛，无发热。如黄疸性质为梗阻性，欲明确梗阻部位，选择下列检查手段为最优的是

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