患者，男性，52岁。既往乙肝病史30余年。因“全身黄染伴乏力3天，神志不清1天”入院。查体:神志朦胧，全身皮肤及巩膜黄染，未见肝掌、蜘蛛痣，肝脾肋下未触及；血总胆红素435μmol/L，ALT1256U/L。其肝功能异常发生的基础是

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