案例：患者，男性，47岁。既往体健。本次因“皮肤黄染伴乏力7天，神志改变3天”入院。查体：神志朦胧，全身皮肤及巩膜黄染，未见肝掌、蜘蛛痣，肝脾肋下未触及。血总胆红素382μmol/L，结合胆红素275μmol/L，ALT582U/L，凝血酶原活动度30%，乙肝表面抗原(+)。患者发生肝衰竭的机制是

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