一足月新生儿，生后4天因不吃、不哭、黄疸而人院。査体发现：患儿全身黄染，反应差，呼吸急促，面色灰，双肺闻及细湿啰音，心率160次/分，肝肋下4cm,脾肋下lcm，质硬，两下肢有硬肿。最可能的诊断是

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