男性，38岁。支气管哮喘急性发作3天，应用氨茶碱、沙丁胺醇、大剂量激素治疗无效。査体:呼吸浅快，口唇发绀，神志不清，双肺呼吸音弱，未闻及哮鸣音。血气分析:Pa0250mmHg,PaCO270mmHg。进一步采取的措施应为

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