患者，女，56岁。患有慢性肾小球肾炎，近期出现恶心呕吐、厌食，伴头痛、意识障碍，于当地医院査肾功能示CCr45ml/min,GFR20ml/(min•1.73m2)，诊断为慢性肾衰竭。该患者的CRF分期为

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