患者，女，52岁。双面颊蝶形红斑,斑疹斑块暗红，两手白紫相继，两腿青斑如网，脱发，鼻衄，关节肿痛，月经延期，小便短赤，有蛋白血尿，低热，烦躁多怒，舌光，脉涩数。实验室检查:尿蛋白（++)，24小时尿蛋白定量1.2g/d,BUN187μmol/L。该患者首选方剂是

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