患者，男，65岁。反复出现上腹痛，发作无明显规律，进食易饱，纳差，腹胀，神疲乏力，面色无华，少气懒言，动则气促，体重下降;舌苔薄白，舌质淡白，舌边有齿痕，脉沉细无力。胃镜见浸润性溃疡，病变超过黏膜下层。该病中晚期最常见的体征是

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