男性，40岁。水肿、少尿2周，BP 170/90mmHg，尿蛋白定量3g/24h，尿红细胞 40/HP，血肌酐560umol/L，血红蛋白82g/L，血抗GBM抗体阳性，泌尿系彩超提示双肾大小正常，肾脏病理:新月体性肾炎。其发病机制主要是

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