某患者，女性，59岁，反复低热5个月余，伴四肢大小关节肿痛。血白细胞8 .7x109/L，血 红蛋白89g/L，ANA ( - )，RF ( + )，拟诊为类风湿关节炎。有助于该病与系统性红斑狼疮相鉴别的是

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