患者，男，27岁。厌油伴乏力、纳差，皮肤黄染1周，伴黑便，尿少，神智障碍2天。查体示:神志不清，皮肤、巩膜明显黄染，全身可见散在瘀斑，腹部膨隆，肝脾肋下未触及，肠鸣音低下，腹水Ⅱ度。该患者最可能的诊断是

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