Chromosome changes in hematologic neoplasms are-最需题库

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1Auer rods are inclusions found in
A.myelobfasts
B.lymphoblasts
C.erythrocytes
D.prolymphocytes
E.megakaryocytes
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2The FAB classification is used to divide acute leukemias into groups according to
A.immunology
B.clinical presentation
C.cytogenetics
D.morphology
E.molecular phenotype
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3Immunologic phenotyping of the blast cells is important to
A.help determine cell lineage
B.identify the etiology of the leukemia
C.determine if cytogenetic analysis is necessary
D.replace the need to do multiple cytochemical stains
E.replace the morphologic detection
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4The largest cell found in a normal bone marrow aspirate is the
A.osteoblast
B.megakaryocyte
C.myeloblast
D.pronormoblast
E.metagranulocyte
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5The preferred site for bone marrow biopsy in an adult is the
A.second intercostals space on the sternum
B.any of the thoracic vertebrae
C.anterior or posterior iliac crest
D.anterior head of the femur
E.skull
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6A common characteristic of acute lymphocytic leukemia is
A.a leukemia of older persons
B.bone and joint pain
C.many blast cells with Auer rods
D.leykocytopenia
E.many blast cells with positive POX stain
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7A leukemia that shows a profusion of granulocytes at all stages of development，with the majority of cells being myelocytes and segmented neutrophils，is
A.AML
B.CML
C.ALL
D.CLL
E.MDS
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8The most prominent cell line in CML is the
A.erythroid
B.myeloid
C.megakaryocyte
D.fibroblast
E.lymphoid
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9The Philadelphia chromosome is a gene fusion from a translocation of
A.chromosomes 8 and 14
B.chromosomes 9 and 22
C.chromosomes 12 and 17
D.chromosomes 15 and 17
E.chromosomes 11 and 17
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10Molecular analysis by RT-PCR revealed the presence of a BCR/ABL fusion product.Based on this information，what myeloproliferative disorders is present
A.CML
B.PV
C.ET
D.MMM
E.MDS
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