Molecular analysis by RT-PCR revealed the presence of a BCR/ABL fusion product.Based on this information，what myeloproliferative disorders is present

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• 1The Philadelphia chromosome is a gene fusion from a translocation of

  A.chromosomes 8 and 14

  B.chromosomes 9 and 22

  C.chromosomes 12 and 17

  D.chromosomes 15 and 17

  E.chromosomes 11 and 17

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• 2The most prominent cell line in CML is the

  A.erythroid

  B.myeloid

  C.megakaryocyte

  D.fibroblast

  E.lymphoid

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• 3A leukemia that shows a profusion of granulocytes at all stages of development，with the majority of cells being myelocytes and segmented neutrophils，is

  A.AML

  B.CML

  C.ALL

  D.CLL

  E.MDS

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• 4A common characteristic of acute lymphocytic leukemia is

  A.a leukemia of older persons

  B.bone and joint pain

  C.many blast cells with Auer rods

  D.leykocytopenia

  E.many blast cells with positive POX stain

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• 5Chromosome changes in hematologic neoplasms are

  A.present in AL but not MPD or MDS

  B.nonrandom

  C.associated with a poor outcome

  D.not usually present

  E.associated with a good outcome

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• 6Which of the following is not typical of an MPD at the time of diagnosis

  A.hypercellular bone marrow

  B.anemia

  C.leukoerythroblastosis

  D.predominance of blasts in peripheral blood

  E.hepatosplenomegaly

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• 7下列关于造血干细胞，叙述错误的是

  A.绝大多数表达CD34

  B.低表达或不表达HLA-DR

  C.多数细胞处于G0期或静止期

  D.缺乏特异系列抗原表面标志

  E.是一类失去自我更新能力的细胞群

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• 8临床上首选的骨髓穿刺点是

  A.胫骨

  B.胸骨

  C.棘突

  D.髂后上棘

  E.髂前上棘

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• 9下列通过骨髓检查可确诊的疾病是

  A.缺铁性贫血

  B.急性白血病

  C.淋巴瘤

  D.原发性血小板减少性紫癜

  E.溶血性贫血

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• 10白介素-3的作用是

  A.抑制造血

  B.仅对髓系的增殖有促进作用

  C.多系集落刺激因子

  D.仅对B淋巴系的增殖有促进作用

  E.仅对T淋巴系的增殖有促进作用

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