上述患者因病情较重收人病房，经用大剂量氢化可的松、氨茶碱等药物滴注，症状未能缓解，痰黏稠难以咳出，进食极少。査体:汗多，心率120次/分，呼吸音低，双肺哮鸣音明显减少，白细胞6.9X10S/L，红细胞比积56%，血气分析PaC0245mmHg,Pa0260mmHg,pH7.33。此时首选的治疗是

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